WASHINGTON (AP) 鈥� A long-awaited review of prescription opioid medications, including their risks and contribution to the U.S. overdose epidemic, is still underway at the Food and Drug Administration, the agency's commissioner said Tuesday.
Dr. Robert Califf wrote in a entry that the FDA is still studying 鈥渨hat revisions are needed to support appropriate use鈥� of opioid painkillers and 鈥渓essons learned鈥� by the agency. The update comes as part of a broader outline of the FDA's ideas and initiatives for combating drug misuse and addiction.
Califf told The Associated Press that the sheer scale of the epidemic makes potential remedies a challenge.
鈥淎lmost everything that we want to do involves some other entity or part of society that we need to work with to figure things out," Califf said in an interview Tuesday.
Califf promised to conduct a full review of FDA鈥檚 approach to opioids, including their prescribing instructions, to clinch Senate confirmation early this year. He told the AP that the public would soon hear 鈥渁 lot more about this."
Part of the delay in reassessing the drugs is that makers of long-acting opioids didn't originally study the medications' effectiveness for long-term pain, which carries risks of addiction and overdose. FDA-mandated studies to get at that question have dragged on for years.
鈥淔DA does its best when it has high quality evidence, and we don鈥檛 have high quality evidence now,鈥� Califf said, adding that it may ultimately take government-run studies to answer the question of long-term opioid safety and effectiveness.
Tuesday's update is also unlikely to appease Califf's critics in Congress, including five Senate Democrats who , largely over concerns that the FDA hasn鈥檛 taken bolder action to reduce opioid prescribing and misuse.
It鈥檚 not the first attempt at a reset on opioids for the FDA 鈥� or even for Califf. During his brief stint as FDA commissioner at the end of the Obama administration, Califf had also vowed to conduct a 鈥渟weeping review鈥� of opioids.
Dr. Andrew Kolodny, an FDA critic who has testified against drugmakers in court, said Califf must do more than review FDA's 鈥渓essons learned鈥� on opioids.
鈥淗e also needs to take on the heavier lift of correcting past mistakes鈥� by removing unproven medications from the market, said Kolodny, who leads a group that favors tighter opioid prescribing.
Last year, U.S. overdose deaths soared to a record of 107,000, driven overwhelmingly by fentanyl and other illegal opioids. Opioid prescriptions have fallen about 40% in the last decade but deaths tied to the medications remain at 13,000 to 14,000 per year.
Califf's post lays out a framework for combating drug addiction and overdoses overall, focusing on reducing inappropriate prescribing, developing new addiction and overdose therapies and shutting down suppliers of illicit drugs.
But many of the agency's specific ideas have failed to gain traction.
For example, a recent FDA proposal that would require pharmacies to dispense 鈥渕ail-back鈥� envelopes with every opioid prescription has faced resistance from pharmacists, drugmakers and other groups. Elsewhere the FDA has tried for nearly a decade to require doctors and other health professionals to undergo training in safe opioid prescribing. That effort has been stalled over questions of whether it requires action by Congress or other government agencies. Medical societies generally oppose any blanket requirement.
Califf said the FDA continues to work with other federal officials to find a way to implement broader training.
鈥淚鈥檓 personally in favor of mandatory education," Califf said, but it must match "the needs of the clinicians, which I think is very hard to do.鈥�
Califf said another priority will be encouraging the development of an over-the-counter version of naloxone, the medication that can reverse opioid overdose. Most states have passed measures allowing pharmacists to dispense the drug without a prescription, but an over-the-counter version would further expand access.
Even that proposal could have unintended consequences, if consumers are unable to afford naloxone that's no longer covered by insurance.
鈥淲e know that more naloxone is needed,鈥� Califf said. 鈥淭he question is how to do that.鈥�
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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute鈥檚 Department of Science Education. The AP is solely responsible for all content.
Matthew Perrone, The Associated Press
