VANCOUVER 鈥� An uninterested pharmaceutical industry and the conundrum of finding a convincing placebo are two reasons experts say there has been little quality research into medicinal marijuana.
A growing number of Canadians are turning to medical cannabis, despite questions about its risks and effectiveness as a health product.
Marijuana鈥檚 unconventional journey onto the medical market puts it at odds with more mainstream medications, which typically undergo years of costly scrutiny before being approved for use, said Mark Ware, a pain researcher at McGill University Health Centre in Montreal.
Ware said pharmaceutical companies are willing to pay hundreds of millions of dollars for clinical trials because once a drug is approved, they have a window of time to sell it exclusively.
鈥淲hen you think about medications that have been given approval to be sold in pharmacies, that鈥檚 where most if not all of our medications come from,鈥� he said. 鈥淭hat model simply does not hold for much of the classical herbal cannabis research, where you鈥檙e looking for basic claims of efficacy and safety, but not trying to make a formal claim for a product that is going to be patented.鈥�
Ware, who also served as vice-chairman on the federal government鈥檚 task force on legalizing cannabis, said competition among licensed marijuana producers is leading some of them to funnel money toward research in an effort to differentiate their brand from others.
But Dr. Mike Allan, a professor of family medicine at the University of Alberta in Edmonton, said there are few benefits for producers to conduct the research.
鈥淚t鈥檚 already at market so there鈥檚 really no incentive, or virtually no incentive, for licensed producers to take the money they鈥檙e generating from the sale of these products and reinvest it in research,鈥� Allan said.
Ware said another dilemma in conducting research on medical marijuana is the absence of a plausible placebo, especially because study participants often have experience using cannabis and recognize if they have been placed in the study or control group.
鈥淎ccess to a credible placebo may seem like an odd thing to have as a challenge,鈥� Ware said.
鈥淏ut bear in mind that many of these studies are placebo-controlled, so you need a drug which is a credible placebo 鈥� looks and smells and for all intents and purposes pretends it is cannabis when, in fact, it does not have the active ingredient you are testing.鈥�
