Lazio, Napoli and reigning champion Atletico Madrid were among the 13 teams to qualify for the knockout stage of the Europa League on Thursday.
However, there was a setback for another of the competition's big names as Liverpool was held to a frustrating 2-2 draw at home to Young Boys, leaving the English side's hopes of progressing to the last 32 in the balance.
Liverpool, a five-time European champion, will be eyeing one of the remaining five qualifying spots in the final round of games in two weeks' time but others can take it easy.
Raul Garcia's early goal earned Atletico a 1-0 victory over Hapoel Tel Aviv, allowing the Spanish side to progress to the last 32 from Group B with Viktoria Plzen.
A goalless draw at home to Tottenham was enough to put Lazio through in Group J, on a day fans of the Italian club were suspected of involvement in a hooligan attack in Rome that led to seven Spurs fans being hospitalized.
Napoli won 2-1 at AIK Stockholm to seal a top-two spot in Group F with Dnipro, which beat PSV Eindhoven away by the same scoreline to eliminate the Dutch hosts.
Wealthy Russian club Anzhi Makhachkala went through with a 2-0 home win over Udinese, courtesy of goals from Christopher Samba and Samuel Eto'o, in the group containing Liverpool.
The other clubs booking their last-32 spots on Thursday were Newcastle, Bordeaux, Fenerbahce, Borussia Moenchengladbach, Genk, Sparta Prague and Levante.
Athletic Bilbao, last season's finalist, was knocked out without even playing following the cancellation of its match against Hapoel Kiryat Shmona because of the fighting in Israel. Sparta knocked out Bilbao by drawing 1-1 at already-qualified Lyon in Group I.
The top two teams in each of the 12 groups go through, where they will be joined by the eight third-place finishers in the Champions League.
