Here are 12 TIFF titles already generating buzz:
Anna Karenina - Keira Knightley reunites for a third time with director Joe Wright in this big-screen adaptation of Tolstoy's classic novel.
Bad 25 - Director Spike Lee embarks on a behind-the-scenes look at the turbulent period that ushered in Michael Jackson's transformation from teen pin-up to troubled icon.
Cloud Atlas - The David Mitchell novel on which this film is based is a sprawling work that jumps across time, borders and genres.
The Company You Keep - The Sundance Kid will hit TIFF to talk up this hotly anticipated political thriller about a militant Weather Underground activist on the run from a journalist.
Looper - Unlike some previous kick-off selections, this movie has "big hit" written all over it.
The Master - Big screen powerhouse Philip Seymour Hoffman plays a spiritual guru who develops a cult-like organization not unlike Scientology, while Joaquin Phoenix is a troubled Second World War vet who falls under his tutelage.
Midnight's Children - Director Deepa Mehta and Booker Prize-winning author Salman Rushdie make up the dream team behind this bigscreen adaptation of Rushdie's sweeping novel about India's early days of independence.
Much Ado About Nothing - This modern-day version of the beloved William Shakespeare play was shot entirely at filmmaker Joss Whedon's house in California over 12 days.
On The Road - Walter Salles' adaptation of the seminal Jack Kerouac book is buzzy not so much for the film itself as it is for its scandal-plagued star, Kristen Stewart.
The Place Beyond the Pines - Star Ryan Gosling has worked with most of these producers several times now, on lauded titles including Half Nelson and Blue Valentine. The A-list cast also includes Eva Mendes, who reportedly started dating Gosling onset.
Seven Psychopaths - Colin Farrell plays a screenwriter who gets ensnared in organized crime when his friends kidnap a gangster's adorable Shih Tzu.
West of Memphis - Celebs including Johnny Depp appear in this documentary about the so-called West Memphis Three, a trio of teens who were convicted of murdering three young boys in Arkansas in 1994.
